• Custom development of state-of-the-art scientific concepts addressing client-specific questions and problems in pharma, diagnostics, and biotech industry, ready for implementation.
• Collaboration in full discretion; no need for the customer to become visible.
• Configuration and execution of pilot studies as implementation of new scientific concepts building on a comprehensive network of academic experts, research groups, research institutes, and biotech as well as life sciences technology companies.
• Configuration and execution of feasibility and proof-of-concept studies including the realization of technological prototype solutions as a basis for practical assessment.
• Scientific consulting for the implementation of innovative scientific concepts and technologies.

Mapping and monitoring of

• Microbial and cellular communication
• System-biological states of dysfunction (disease biology)
• Hologenomic ecosystem dynamics (microbial dysbiosis)
• Rheostatic and allostatic response

Identification of molecular players as biomarkers and biomarker profiles

• Regulatory and structural molecular entities

1. 1. noncoding nucleotides
   2. structural RNAs

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• Functional molecular entities

1. mRNAs
2. proteins

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Therapeutic concepts and molecular active principles

• Prediction of target structures and interactions

1. Modeling of affinity and specificity
2. Structural stability assessment

• Molecular design

1. Structure/activity relationships
2. Lead structure analysis and comparison

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Modeling and simulation of

• Pharmacokinetic systems (ADME)

1. drug absorption
2. drug distribution
3. drug metabolization and elimination
4. drug potency prediction
5. drug delivery systems

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• Pharmakodynamic systems

1. physiologic response
2. systems biological response

• Bioinformatics and biocomputing

1. biomolecular structure analysis
2. structure prediction

• Molecular systems modeling

1. biological systems modeling
2. polymer modeling

• Data mining
• Knowledge engineering
• Biostatistics

Configuration, organization, and execution of

• Pilot studies
• Feasibility studies
• Proof-of-principle studies
• Proof-of-concept studies

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Computational services for translating preclinical study data into references for First-In-Human studies.

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