AAGCAGGTTGTTAGGCACTGGTGTCTAAAATTTGGTCAAATTTTAGACACCATGAGCAATAGCACATTATCAACTGTGATCATTTAATTATCTCTTGTTCTCCCTAGCTACATTTTCTGCCTGTTGTCATAAAGATTAAG
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Contract Research & Development
for the Life Science Industries

- We help you to solve your scientific problems -



SERVICES

  • Development and validation of scientific concepts and technological solutions

  • Custom development of state-of-the-art scientific concepts addressing client-specific questions and problems in pharma, diagnostics, and biotech industry, ready for implementation.
  • Collaboration in full discretion; no need for the customer to become visible.
  • Configuration and execution of pilot studies as implementation of new scientific concepts building on a comprehensive network of academic experts, research groups, research institutes, and biotech as well as life sciences technology companies.
  • Configuration and execution of feasibility and proof-of-concept studies including the realization of technological prototype solutions as a basis for practical assessment.
  • Scientific consulting for the implementation of innovative scientific concepts and technologies.

  • Development of diagnostic concepts

Mapping and monitoring of

  • Microbial and cellular communication
  • System-biological states of dysfunction (disease biology)
  • Hologenomic ecosystem dynamics (microbial dysbiosis)
  • Rheostatic and allostatic response

Identification of molecular players as biomarkers and biomarker profiles

  • Regulatory and structural molecular entities
    1. noncoding nucleotides
    2. structural RNAs

(Click image to enlarge)

Human Tyr tRNA

 

  • Functional molecular entities
  1. mRNAs
  2. proteins

(Click image to enlarge)

Staphylococcus aureus toxin alpha-hemolysin (RCSB PDB-ID 4P24).

  • Development of therapeutic concepts

Therapeutic concepts and molecular active principles

  • Prediction of target structures and interactions
  1. Modeling of affinity and specificity
  2. Structural stability assessment
  • Molecular design
  1. Structure/activity relationships
  2. Lead structure analysis and comparison

 

(Click image to enlarge)

U4/U6 di-snRNA (RCSB PDB-ID: 2N7M), part of the eukaryotic spliceosome.

  • Development of pharmacologic concepts

Modeling and simulation of

  • Pharmacokinetic systems (ADME)
  1. drug absorption
  2. drug distribution
  3. drug metabolization and elimination
  4. drug potency prediction
  5. drug delivery systems

(Click image to enlarge)

10 µM Particles, with kind permission from microParticle GmbH, Berlin.

 

  • Pharmakodynamic systems
  1. physiologic response
  2. systems biological response

  • Scientific services and scientific consulting

  • Bioinformatics and biocomputing
  1. biomolecular structure analysis
  2. structure prediction
  • Molecular systems modeling
  1. biological systems modeling
  2. polymer modeling
  • Data mining
  • Knowledge engineering
  • Biostatistics

  • Study design and realization

Configuration, organization, and execution of

  • Pilot studies
  • Feasibility studies
  • Proof-of-principle studies
  • Proof-of-concept studies

(Click table to enlarge)

Contingency Table and Fisher Test

  • Translational Pharmacology

Computational services for translating preclinical study data into references for First-In-Human studies.

 

(Click schema to enlarge)

Workflow Translational Pharmacology